Diego Alfredo Lugano Moreno (born November 2, 1980 in Canelones) is a Uruguayan international football central defender who currently plays for Fenerbahçe in Turkish Super League. He has previously played for Plaza Colonia, Nacional and São Paulo. He is also captain of Uruguay national football team.
In 2005, playing for São Paulo, he led his team to titles in the Campeonato Paulista, the Copa Libertadores, and FIFA Club World Championship. That same year, Lugano was awarded a prize as South America's best defender. In 2006, he carried his squad to runner-up in the Copa Libertadores.
He joined Fenerbahçe in 2006. He was suspended for 5 weeks after the Galatasaray derby in 2008-2009 season and conceded a red card.
He is married and has two sons and one daughter, Bianca.